I use RTX VSR + RTX VSR HDR + Rife V2.26 in 1440p at 72 FPS througt MPC-HC x64
It's totaly possible be carefull of performance issues because a t 4k is not the same thing
Normaly you can set up this on
First : VIEW->Option->Internal Filter->Video decoder-> put hardware decoder tu use to DXVA2 (copy back)
Second : VIEW->Option->Playback->Output-> select in directShow video Mpc Video Renderer -> Check RTX VIDEO HDR and Request Super Resolution to For < = 1080 p
Normaly it's work
My settings for anime is