Hi all, I experienced this issue (MPC-HC freezes soon after starting playback if GPU acceleration is active).
It seems that nVidia has removed CUDA support from the Win10 driver.
Simple solution: Download and install the CUDA developer package from https://developer.nvidia.com/cuda-downloads.
You can then use full GPU acceleration.
I unchecked the Samples and the Visual Studio Integration during installation to save space.
Hope this helps someone else experiencing the same.