Been using SVP for over a year now. I still find myself wondering about the settings all the time.
These are the settings I've found that worked pretty well for me (at least for anime):
Uniform/Adaptive (Pretty much the same from my experience, as long as you don't mind some artifacts)
Sharp/Standard/Complicated (Sharp will give you less artifacts but standard and complicated are much smoother. I personally prefer complicated.)
Artifacts Masking disabled (Using weakest/weak/... reduce smoothness. Even the slightest artifact masking reduces smoothness quite a bit for me).
Half Pixel (for increased precision, always been better for me, as long as you can spare the cpu).
12 px. Average 2 for Motion Vector grid (I've found this setting to actually work wonders for smoothness. Any lower and you get noticeable artifacts).
Decrease grid step by 2 with global refinement (ABSOLUTELY must use this setting with anime if you can spare the cpu. Without this hardsubs are unbearable).
Search radius: small and fast (This one I have not tested too extensively I was wondering if anyone could explain this thoroughly. What to use with anime, and not with).
Wide Search: strongest (Not too sure about this one either. If you can spare the CPU use strongest)
Large Width Coarse (Irrelevant setting applies to 4k and 2k video which I never have).
Repeat frame/Blend adjacent (I have yet to notice a difference here but I have not tested enough. I stick with repeat).
Like Nintendo Maniac mentioned, I also found a 72Hz overclocked monitor to be quite smoother than 60Hz standard.
I'm wondering how many threads I should use with my CPU.
System Specs:
AMD FX-8350 Vishera 8-Core OC'd to 4.6 GHz
GeForce GTX 760
Monitor: ASUS VS247H-P OC'd from 60Hz to 72Hz.
Windows 10